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Letter to Shareholders

    Dear Shareholder:
    As most of you know, in late March, Andrew & Williamson Sales, Co. (A&W),
a recently acquired subsidiary of Epitope, Inc., initiated a voluntary recall
of frozen strawberries following an outbreak of Hepatitis A in several schools
in Michigan.  Through epidemiologic studies, the Centers for Disease Control
and Prevention (CDC) associated A&W's strawberries with the outbreak.  To
date, health officials have reported 199 confirmed cases of Hepatitis A.
    We take this opportunity to update you on this important matter and to
discuss the challenges it has presented to our company.  Our first concern is
to protect the public health, and we are working closely with various
governmental agencies to ensure that prompt and appropriate action has been
and continues to be taken toward that end.
    As you would expect, we have fielded numerous questions about the recall.
We would like to share with you our answers to the ones most frequently asked.
They are attached for your information.
    Our primary concern is an immediate one, to do everything we can to
cooperate with the FDA and other agencies in protecting the public.  These
have been difficult days for Epitope, but we believe the course we have set
and the actions taken have benefited both consumers and the long term health
of the company.
    Finally, we wish to thank you for your encouragement and support.  Please
continue to contact us with your questions.  We will keep you advised about
our progress in facing this challenge.

    Adolph J. Ferro, Ph.D.                           Roger L. Pringle
    President and Chief Executive Officer            Chairman

    April 1997

    Q1:  What is Hepatitis A?
    A:   Hepatitis A is a virus which can cause flu-like symptoms.  While
unpleasant, the virus is rarely life-threatening and does not typically
produce permanent damage.  Additional information is available from the
Centers for Disease Control at http://www.cdc.gov.

    Q2:  How many people have been affected by this outbreak?
    A:   To date, health officials have notified us of 199 confirmed cases,
all in Michigan.

    Q3:  Could there be more cases?
    A:   The average incubation period from time of contact with Hepatitis A
contaminated food is 28 days.  It is possible additional cases will be
confirmed, although so far, none have been reported beyond those in Michigan.

    Q4:  What is the source of the virus associated with this outbreak?
    A:   Based on epidemiologic evidence, the CDC believes that certain A&W
frozen strawberries were associated with the outbreak.  The berries were
processed by A&W on three days in 1996:  April 19, May 7 and May 8.
Introduction of the virus could have occurred during harvesting, processing or
    Available scientific methods do not permit reliable direct detection of
Hepatitis A in strawberries.  Therefore, it is unlikely that the point at
which the contamination occurred will ever be known, or that the suspected
contamination will be confirmed.

    Q5:  What is the extent and nature of the product recall?
    A:   In cooperation with FDA and other governmental agencies, A&W is
recalling all frozen strawberries potentially associated with the outbreak.
By FDA definition, this is a Class II recall.  A recall is "Class II" when the
product in question "may cause temporary or medically reversible adverse
health consequences" or when "the probability of serious adverse health
consequences is remote."  By comparison, a Class I recall would involve a
life-threatening contamination.

    Q6:  Where were the strawberries grown and processed?
    A:   The recalled strawberries were grown in Mexico and processed in A&W's
facilities in San Diego, CA.

    Q7:  What is the impact of this on Agritope and Epitope, and what actions
are we taking on behalf of our companies?
    A:   Several important points here...

        1.  Background:  Epitope acquired A&W on December 12, 1996.  Prior to
            the acquisition, A&W contracted to supply U.S. grown strawberries
            for use in the USDA school lunch program.
              On November 27, 1996, A&W's former CEO falsely certified to the
            USDA that the berries were grown in the United States.  In fact,
            the berries were grown in Mexico.  Epitope did not know of these
            facts when it acquired A&W.  At the time of the acquisition,
            Epitope received contractual assurances from the sellers,
            including the former CEO, that A&W was in compliance with all
            applicable laws and regulations and was not in default under its
              Upon learning of the false certification, Epitope immediately
            contacted the USDA.

        2.  Lawsuit:  On Monday, April 7, 1997, Epitope filed a lawsuit in
            federal court seeking to rescind the acquisition of A&W.  We
            believe we were seriously defrauded by the sellers in spite of our
            careful due diligence before consummating the acquisition.  The
            lawsuit seeks full restitution from the former owners of A&W.
              It is important to note that our pre-acquisition due diligence
            was comprehensive and rigorous.  We were assisted in the
            acquisition by recognized professional experts including Price
            Waterhouse LLP, Vector Securities International, Inc., and various
            prominent law firms.  At the time of our acquisition, A&W enjoyed
            an excellent reputation in the fresh produce business.  For
            example, the Red Book Credit Services, which provides information
            for the produce industry, evaluated A&W and awarded them their
            Business Character Award for establishing and maintaining a
            reputation of high ethical trading practices, business competence
            and financial stability.

        3.  Liabilities:  Epitope, Inc. and Agritope, Inc. were not involved
            in events leading to the recall or the false certification.  A&W,
            even as a subsidiary of Epitope, is a separate legal entity that
            should be alone responsible for its actions.  We believe that the
            exposure of Epitope and Agritope is limited by the fact that we
            acquired A&W after these activities occurred and had no prior
            knowledge of the false certification.
              Epitope has been named in lawsuits filed on behalf of persons
            claiming damages relating to the Hepatitis A outbreak and A&W's
            distribution of strawberries that have been recalled.  Some of the
            claims may be covered by insurance.  Epitope and A&W have tendered
            defense to their respective insurers.

        4.  Disposition of A&W:  Our board of directors has concluded that A&W
            can no longer serve the purposes for which we acquired it, to
            serve as part of a vertically integrated organization producing
            superior, genetically engineered produce.  As a result of this
            conclusion, we are conducting active negotiations with the former
            A&W shareholders to rescind our acquisition. If the current
            negotiations produce an acceptable agreement, we will dismiss our

    Q8:  What effect will this matter have on the scheduled April 29, 1997
annual meeting of Epitope shareholders and on the targeted stock proposal
(i.e., creation of Epitope Medical Products stock and Agritope stock as
separate securities)?
    A:   In light of the recent developments concerning A&W, we will
reschedule the annual meeting to June 17, 1997, to allow revision of the
prospectus/proxy statement.  We will communicate with you as soon as new
arrangements are in place.
    We are also reevaluating  the targeted stock proposal.

    Q9:  What effect will this matter have on the future of Agritope?
    A:   We believe Agritope has a bright future.  Our fundamental technology
and strategy remain sound.  Our Beaverton-based R&D unit continues to develop
genetically-engineered fruits and vegetables.  In addition, we recently
acquired access to five new genes of potentially significant economic
importance from the Salk Institute, a world-renowned research center.
    Vinifera, Agritope's grape plant subsidiary, is also expanding facilities
and grapevine production to meet market demand for our plants.  In an
important expression of confidence from investors, two minority shareholders
of Vinifera have agreed to purchase additional shares of Vinifera common stock
for a total of $1,000,000, which will be used to fund the expansion.  The
transaction is expected to close in the next few days.
    We are moving ahead with a number of business initiatives in these and
other agricultural business areas and look forward to discussing them with you
at our annual meeting.

    Q10: What effect will this matter have on Epitope Medical Products?
    A:   The A&W events described in this letter have had minimal effect on
Epitope Medical Products.  EpiScreen(TM) sales to the insurance industry are
brisk and improving, and SmithKline Beecham has increased its orders for
OraSure(R).  We are continuing with important product development work,
including our rapid OraQuick test and a second generation of OraSure.  After
our long effort to develop and commercialize this important oral fluid
diagnostic technology, product sales and interest in the technology are
increasing.  Again, we will update you at the annual meeting.

    In summary, our first concern is to do everything we can to cooperate with
the FDA and others in protecting the public's well-being.  We will continue to
keep you apprised of developments relating to A&W.
    Our future is bright.  We are being tested, but we are doing what is
right.  We are grateful for your patience and welcome your questions at any

                                    * * *

    Statements in these materials about future events or performance are
forward-looking statements.  Actual results could be quite different.
Important factors that could affect results include damage to business
reputation resulting from the Hepatitis A outbreak; loss or impairment of
sources of capital; unexpected liabilities; development of competing products;
market acceptance of oral testing and genetically engineered produce;
development of other methods for controlling fruit and vegetable ripening;
crop failure; changes in federal or state law or regulations; and loss of key
personnel.  Although forward-looking statements help to provide complete
information about the Company, readers should keep in mind that forward-
looking statements are much less reliable than historical information.

Source: EPITOPE Inc.

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